OTUD7B

Across TCGA patient cohorts, OTUD7B mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTUD7B-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and Rad50. Each is linked with OTUD7B in more than 3 cancer types. Because this analysis shows association rather than direction, both OTUD7B-to-partner and partner-to-OTUD7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by OTUD7B-low versus OTUD7B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTUD7B→partner) and Y-score (partner→OTUD7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.115	+2.815	.010	.036	3	4
UCEC	ATM →	-0.603	-2.378	<.001	<.001	3	4
UCEC	Rad50 →	-0.207	-1.777	.007	.002	3	3
LUSC	ACC_pS79 →	+0.571	+2.816	.002	.036	3	2
SKCM	TSC1 →	-0.441	-3.169	<.001	.019	3	2
COAD	Notch1 →	+0.293	+2.815	.003	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Caspase-7-cleavedD198 by OTUD7B expression — COAD

Explore this box plot interactively →