OTUD7A

Across TCGA patient cohorts, OTUD7A mutation is significantly associated with the RNA expression of many other genes, with 2,396 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTUD7A-associated genes across cancer lineages are CRYGB, RPA1, and KIF23. Each is linked with OTUD7A in more than 2 cancer types. Because this analysis shows association rather than direction, both OTUD7A-to-partner and partner-to-OTUD7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYGB grouped by OTUD7A-low versus OTUD7A-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTUD7A→partner) and Y-score (partner→OTUD7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CRYGB →	+0.147	+4.957	<.001	<.001	3	3
UCEC	RPA1 →	+0.461	+1.773	.003	.008	3	3
COAD	KIF23 →	+0.585	+3.236	.002	.008	3	3
COAD	HAUS1 →	+0.624	+3.513	.002	.002	3	3
UCEC	CKAP2L →	+0.594	+2.415	.002	.003	3	3
COAD	BUB1 →	+0.591	+3.459	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,396 associations by consensus.

CRYGB by OTUD7A expression — LUSC

Explore this box plot interactively →