OTUD7A

Across TCGA patient cohorts, OTUD7A mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTUD7A-associated genes across cancer lineages are Akt, 4E-BP1, and Notch1. Each is linked with OTUD7A in more than 2 cancer types. Because this analysis shows association rather than direction, both OTUD7A-to-partner and partner-to-OTUD7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt grouped by OTUD7A-low versus OTUD7A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTUD7A→partner) and Y-score (partner→OTUD7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt →	-0.207	-2.212	.013	.010	3	3
UCEC	4E-BP1 →	+0.215	+3.584	.031	.002	3	3
UCEC	Notch1 →	+0.167	+2.247	.001	.001	3	2
UCEC	PDCD4 →	-0.588	-2.459	<.001	.018	3	2
UCEC	Rad50 →	-0.222	-1.502	.012	.030	3	2
UCEC	STAT3_pY705 →	-0.381	-1.847	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Akt by OTUD7A expression — UCEC

Explore this box plot interactively →