OTUD6B

Across TCGA pan-cancer cohorts, OTUD6B Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated OTUD6B data layer compared with 30 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher OTUD6B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated OTUD6B expression acts as an unfavorable survival marker.

HNSC, LUAD, and CESC are the cancer types where OTUD6B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.001	0.751	<.001	48	view →
LUAD	OS	Median	III,IV	0.147	0.679	.001	21	view →
CESC	DFS	Median	III,IV	0.240	0.726	.015	6	view →
ESCA	OS	Median	II,III,IV	0.301	0.707	.006	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

OTUD6B–HNSC (OS)

Open the HNSC breakdown →