OTUD5

Across TCGA pan-cancer cohorts, OTUD5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated OTUD5 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher OTUD5 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated OTUD5 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where OTUD5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.858	0.298	.010	13	view →
LUAD	DFS	Quartile	All	0.892	0.458	.014	11	view →
HNSC	OS	Median	All	0.452	1.000	.025	6	view →
LSCC	DFS	Tertile	All	0.985	0.859	.032	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

OTUD5–PDAC (OS)

Open the PDAC breakdown →