OTUD5

Across TCGA patient cohorts, OTUD5 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTUD5-associated genes across cancer lineages are Cyclin-E2, EGFR_pY1068, and FASN. Each is linked with OTUD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both OTUD5-to-partner and partner-to-OTUD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by OTUD5-low versus OTUD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTUD5→partner) and Y-score (partner→OTUD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.124	+1.807	.031	.004	3	2
UCEC	EGFR_pY1068 →	-0.218	-1.906	.010	.015	3	1
UCEC	FASN →	+0.367	+2.459	.006	.018	3	1
UCEC	FOXO3a_pS318_S321 →	-0.099	-1.575	.019	.017	3	1
UCEC	Heregulin →	-0.114	-1.514	.006	.015	3	1
UCEC	Ku80 →	+0.223	+1.527	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Cyclin-E2 by OTUD5 expression — UCEC

Explore this box plot interactively →