OTUD4

Across TCGA pan-cancer cohorts, OTUD4 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of OTUD4’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where OTUD4 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types OTUD4 is over-expressed in tumor.

CCRCC, HNSC, and COAD are the cancer types where OTUD4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OTUD4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	+0.355	<.001	11	view →
HNSC	Male	III,IV	+0.277	<.001	8	view →
COAD	All	All	+0.210	<.001	8	view →
PDAC	Female	All	+0.184	.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

OTUD4–CCRCC

Open the CCRCC breakdown →