OTUD1

Across TCGA pan-cancer cohorts, OTUD1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated OTUD1 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher OTUD1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated OTUD1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

UCEC, LUAD, and HNSC are the cancer types where OTUD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.814	1.000	.016	18	view →
LUAD	DFS	Quartile	All	0.841	0.982	.010	17	view →
HNSC	DFS	Tertile	III,IV	0.343	0.763	.007	11	view →
PDAC	DFS	Quartile	II,III,IV	0.448	0.221	.032	7	view →
GBM	OS	Median	All	0.883	0.717	.015	3	view →
LSCC	OS	Median	All	0.816	0.929	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

OTUD1–UCEC (DFS)

Open the UCEC breakdown →