OTUB2

Across TCGA pan-cancer cohorts, OTUB2 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated OTUB2 data layer compared with 28 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher OTUB2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated OTUB2 expression acts as an unfavorable survival marker, although some lineages such as STAD show a favorable association.

HNSC, LUAD, and THCA are the cancer types where OTUB2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.179	0.752	<.001	54	view →
LUAD	OS	Median	II,III,IV	0.057	0.709	<.001	24	view →
THCA	DFS	Median	All	0.061	0.841	<.001	6	view →
STAD	OS	Median	IV	0.805	0.283	.031	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

OTUB2–HNSC (OS)

Open the HNSC breakdown →