OTUB2

Across TCGA patient cohorts, OTUB2 protein abundance is significantly associated with the protein abundance of many other proteins, with 6,589 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible OTUB2-associated proteins across cancer lineages are MTMR4_S629, AP4E1, and CRYBG2_S491. Each is linked with OTUB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both OTUB2-to-partner and partner-to-OTUB2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, OTUB2 versus MTMR4_S629 in HNSC, with a Pearson correlation of -0.56.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (OTUB2→partner) and Y-score (partner→OTUB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MTMR4_S629 →	-0.634	-0.986	<.001	<.001	3	2
BRCA	AP4E1 →	+0.350	+0.430	<.001	.007	2	3
HNSC	CRYBG2_S491 →	+1.586	+1.008	<.001	<.001	3	2
BRCA	ABHD6 →	+0.405	+0.600	<.001	<.001	3	2
OV	PHF5A →	-0.682	-1.884	<.001	.005	3	2
HNSC	SMC1A →	-0.317	-1.155	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,589 associations by consensus.

OTUB2 vs MTMR4_S629 — HNSC

Explore this scatter interactively →