OTUB2

Across TCGA patient cohorts, OTUB2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTUB2-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and FASN. Each is linked with OTUB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OTUB2-to-partner and partner-to-OTUB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by OTUB2-low versus OTUB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTUB2→partner) and Y-score (partner→OTUB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.382	-3.584	<.001	.002	3	1
UCEC	A-Raf_pS299 →	-0.231	-2.584	<.001	.010	3	1
UCEC	FASN →	+0.350	+2.000	.049	.032	3	1
UCEC	ACC1 →	+0.444	+3.183	.006	.009	3	1
UCEC	JNK2 →	+0.275	+2.000	.002	.032	3	1
UCEC	Ku80 →	+0.228	+2.013	.032	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR_pY1068 by OTUB2 expression — UCEC

Explore this box plot interactively →