OTUB1

Across TCGA pan-cancer cohorts, OTUB1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated OTUB1 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher OTUB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated OTUB1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

PDAC, CCRCC, and COAD are the cancer types where OTUB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.286	0.530	<.001	9	view →
CCRCC	OS	Median	All	0.747	0.913	.001	8	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
UCEC	DFS	Tertile	III,IV	1.000	0.482	.042	4	view →
HNSC	DFS	Median	IV	0.778	0.570	.036	3	view →
LUAD	OS	Quartile	II,III,IV	1.000	0.327	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

OTUB1–PDAC (DFS)

Open the PDAC breakdown →