OTUB1

Across TCGA patient cohorts, OTUB1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTUB1-associated genes across cancer lineages are eIF4E, eIF4G, and GAPDH. Each is linked with OTUB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OTUB1-to-partner and partner-to-OTUB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by OTUB1-low versus OTUB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTUB1→partner) and Y-score (partner→OTUB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.269	+3.700	.006	.001	2	2
UCEC	eIF4G →	+0.386	+3.321	.007	.009	3	1
UCEC	GAPDH →	+0.593	+2.999	.017	.035	3	1
UCEC	Ku80 →	+0.277	+2.598	.011	.006	3	1
UCEC	MAPK_pT202_Y204 →	-0.550	-2.584	.012	.011	3	1
UCEC	mTOR_pS2448 →	-0.193	-3.302	.005	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

eIF4E by OTUB1 expression — UCEC

Explore this box plot interactively →