OTUB1

Across TCGA cell cohorts, OTUB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,661 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible OTUB1-associated GO terms across cancer lineages are Positive regulation of attachment of mitotic spindle microtubules to kinetochore, Regulation of attachment of mitotic spindle microtubules to kinetochore, and CAAX-box protein processing. Each is linked with OTUB1 in more than 16 cancer types. Because this analysis shows association rather than direction, both OTUB1-to-partner and partner-to-OTUB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of attachment of mitotic spindle microtubules to kinetochore grouped by OTUB1-low versus OTUB1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OTUB1→partner) and Y-score (partner→OTUB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.243	+0.919	<.001	<.001	3	17
BONE	Regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.224	+0.900	<.001	<.001	3	15
BONE	CAAX-box protein processing →	+0.147	+0.767	.009	<.001	3	15
URINARY_TRACT	mRNA alternative polyadenylation →	+0.104	+0.922	<.001	<.001	3	14
URINARY_TRACT	Positive regulation of attachment of spindle microtubules to kinetochore →	+0.143	+0.725	.005	.002	3	13
URINARY_TRACT	Regulation of metaphase plate congression →	+0.145	+0.696	.001	.008	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,661 associations by consensus.

Positive regulation of attachment of mitotic spindle microtubules to kinetochore by OTUB1 expression — BONE

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