OTUB1

Across TCGA cell cohorts, OTUB1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OTUB1-associated genes across cancer lineages are MSGN1, PYDC1, and SNTG2. Each is linked with OTUB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OTUB1-to-partner and partner-to-OTUB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by OTUB1-low versus OTUB1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTUB1→partner) and Y-score (partner→OTUB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.056	+3.345	.007	.007	3	1
LARGE_INTESTINE	PYDC1 →	+0.174	+3.347	.007	.005	3	1
LARGE_INTESTINE	SNTG2 →	+0.143	+3.789	.002	.004	3	1
LARGE_INTESTINE	GPR88 →	+0.011	+4.099	<.001	<.001	3	1
LARGE_INTESTINE	TFDP3 →	+0.020	+3.196	.001	.007	3	1
LARGE_INTESTINE	TAFA1 →	+0.280	+3.688	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MSGN1 by OTUB1 expression — LARGE_INTESTINE

Explore this box plot interactively →