OTP

Across TCGA patient cohorts, OTP mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTP-associated genes across cancer lineages are EGFR_pY1068, Gab2, and Ku80. Each is linked with OTP in more than 1 cancer types. Because this analysis shows association rather than direction, both OTP-to-partner and partner-to-OTP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by OTP-low versus OTP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTP→partner) and Y-score (partner→OTP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.256	-2.807	.019	.003	3	1
UCEC	Gab2 →	+0.473	+2.115	.002	.019	3	1
UCEC	Ku80 →	+0.250	+1.598	.015	.044	3	1
UCEC	Notch1 →	+0.216	+3.331	<.001	.005	3	1
UCEC	Paxillin →	+0.333	+3.331	.003	.005	3	1
UCEC	PKC-a →	+0.584	+2.183	<.001	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR_pY1068 by OTP expression — UCEC

Explore this box plot interactively →