OTP

Across TCGA cell cohorts, OTP RNA expression is significantly associated with the go_rna of many other GO terms, with 1,292 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible OTP-associated GO terms across cancer lineages are Regulation of DNA-templated transcription initiation, Regulation of double-strand break repair, and Positive regulation of double-strand break repair. Each is linked with OTP in more than 5 cancer types. Because this analysis shows association rather than direction, both OTP-to-partner and partner-to-OTP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA-templated transcription initiation grouped by OTP-low versus OTP-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OTP→partner) and Y-score (partner→OTP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of DNA-templated transcription initiation →	+0.081	+0.052	<.001	<.001	3	6
OVARY	Regulation of double-strand break repair →	+0.046	+0.020	<.001	.008	3	6
OVARY	Positive regulation of double-strand break repair →	+0.053	+0.021	<.001	.004	3	6
BREAST	Regulation of DNA repair →	+0.046	+0.103	<.001	.008	3	6
LUNG_SCLC	Establishment of protein localization to organelle →	+0.053	+0.950	<.001	.003	3	6
LUNG_SCLC	Regulation of centrosome duplication →	+0.094	+0.516	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,292 associations by consensus.

Regulation of DNA-templated transcription initiation by OTP expression — PANCREAS

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