OTP

Across TCGA cell cohorts, OTP mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OTP-associated genes across cancer lineages are IFNA2, OR5H6, and NABP2. Each is linked with OTP in more than 1 cancer types. Because this analysis shows association rather than direction, both OTP-to-partner and partner-to-OTP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA2 grouped by OTP-low versus OTP-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTP→partner) and Y-score (partner→OTP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IFNA2 →	+0.022	+5.029	<.001	.006	3	1
LUNG_SCLC	OR5H6 →	+0.025	+5.029	<.001	.006	3	1
LARGE_INTESTINE	NABP2 →	+0.515	+3.215	.003	.009	2	1
LARGE_INTESTINE	INTS13 →	+0.623	+3.215	.002	.009	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

IFNA2 by OTP expression — LUNG_SCLC

Explore this box plot interactively →