OTOR

Across TCGA patient cohorts, OTOR mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTOR-associated genes across cancer lineages are 4E-BP1_pT37_T46, ERK2, and JNK2. Each is linked with OTOR in more than 1 cancer types. Because this analysis shows association rather than direction, both OTOR-to-partner and partner-to-OTOR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT37_T46 grouped by OTOR-low versus OTOR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOR→partner) and Y-score (partner→OTOR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1_pT37_T46 →	-0.458	-2.459	.011	.020	3	2
UCEC	ERK2 →	+0.232	+3.321	.012	.010	3	1
UCEC	JNK2 →	+0.261	+2.459	.006	.020	3	1
UCEC	NF-kB-p65_pS536 →	-0.485	-2.999	.027	.035	3	1
UCEC	SLC1A5 →	-0.422	-2.999	.040	.034	3	1
UCEC	ATM →	-0.537	-2.459	.014	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

4E-BP1_pT37_T46 by OTOR expression — UCEC

Explore this box plot interactively →