OTOR

Across TCGA cell cohorts, OTOR RNA expression is significantly associated with the go_rna of many other GO terms, with 1,146 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible OTOR-associated GO terms across cancer lineages are Peptidyl-lysine dimethylation, Regulation of monocyte chemotaxis, and Regulation of ureteric bud formation. Each is linked with OTOR in more than 2 cancer types. Because this analysis shows association rather than direction, both OTOR-to-partner and partner-to-OTOR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-lysine dimethylation grouped by OTOR-low versus OTOR-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOR→partner) and Y-score (partner→OTOR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Peptidyl-lysine dimethylation →	+0.111	+0.015	.003	.008	3	3
LARGE_INTESTINE	Regulation of monocyte chemotaxis →	-0.087	-0.008	.006	.008	3	3
BREAST	Regulation of ureteric bud formation →	+0.593	+0.847	.002	.009	3	3
BREAST	Positive regulation of ureteric bud formation →	+0.593	+0.847	.002	.009	3	3
BREAST	Postsynaptic membrane assembly →	-1.150	-1.064	<.001	<.001	3	3
BREAST	Positive regulation of T cell migration →	-0.141	-1.385	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,146 associations by consensus.

Peptidyl-lysine dimethylation by OTOR expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →