OTOR

Across TCGA cell cohorts, OTOR mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible OTOR-associated genes across cancer lineages are DAZ2, CT47A6, and HSFY2. Each is linked with OTOR in more than 1 cancer types. Because this analysis shows association rather than direction, both OTOR-to-partner and partner-to-OTOR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAZ2 grouped by OTOR-low versus OTOR-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOR→partner) and Y-score (partner→OTOR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DAZ2 →	+0.106	+5.807	<.001	.001	3	1
OVARY	CT47A6 →	+0.030	+5.807	<.001	.001	3	1
LARGE_INTESTINE	HSFY2 →	+0.023	+4.977	<.001	.007	3	1
LARGE_INTESTINE	CD300H →	+0.045	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

DAZ2 by OTOR expression — OVARY

Explore this box plot interactively →