Across TCGA patient cohorts, OTOP2 RNA expression is significantly associated with the RNA expression of many other genes, with 8,733 significant associations in total. ESCA shows the largest number of these associations.

The most reproducible OTOP2-associated genes across cancer lineages are USH1G, CRYBG2, and OTOP3. Each is linked with OTOP2 in more than 18 cancer types. Because this analysis shows association rather than direction, both OTOP2-to-partner and partner-to-OTOP2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOP2→partner) and Y-score (partner→OTOP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	USH1G →	+2.029	+1.117	<.001	<.001	3	19
ESCA	CRYBG2 →	+1.233	+0.672	<.001	<.001	3	15
HNSC	OTOP3 →	+2.696	+0.819	<.001	<.001	3	14
ESCA	TINCR →	+2.130	+0.979	<.001	<.001	3	13
ESCA	SPRR1B →	+5.508	+0.963	<.001	<.001	3	13
ESCA	SCEL →	+3.434	+0.895	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,733 associations by consensus.

Exploration

OTOP2 survival (RNA) · tumor vs normal (RNA) · all OTOP2 data types