Across TCGA patient cohorts, OTOP2 mutation is significantly associated with the RNA expression of many other genes, with 3,946 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTOP2-associated genes across cancer lineages are ULK4P3, RNA5SP160, and CIDECP1. Each is linked with OTOP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both OTOP2-to-partner and partner-to-OTOP2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOP2→partner) and Y-score (partner→OTOP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ULK4P3 →	+0.158	+2.328	.001	.003	3	3
LUSC	RNA5SP160 →	+0.579	+3.717	.001	.006	3	3
UCEC	CIDECP1 →	+0.407	+2.588	<.001	<.001	3	3
UCEC	PRIM1 →	+0.734	+2.032	<.001	<.001	3	3
UCEC	WDHD1 →	+0.747	+2.021	<.001	<.001	3	3
UCEC	ABCF2P1 →	+0.087	+2.640	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,946 associations by consensus.

Exploration

OTOP2 survival (RNA) · tumor vs normal (RNA) · all OTOP2 data types