Across TCGA cell cohorts, OTOP2 mutation is significantly associated with the RNA expression of many other genes, with 88 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OTOP2-associated genes across cancer lineages are TMEM147, GAR1, and ATP5PB. Each is linked with OTOP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OTOP2-to-partner and partner-to-OTOP2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOP2→partner) and Y-score (partner→OTOP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMEM147 →	+0.472	+3.212	.002	.006	3	1
LARGE_INTESTINE	GAR1 →	+0.531	+3.299	.003	.004	3	1
LARGE_INTESTINE	ATP5PB →	+0.477	+3.212	.004	.006	3	1
LARGE_INTESTINE	MAP1S →	+0.537	+3.212	.005	.006	3	1
LARGE_INTESTINE	HAUS8 →	+0.572	+3.212	.001	.006	3	1
LARGE_INTESTINE	PSMA5 →	+0.446	+3.212	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

Exploration

OTOP2 survival (RNA) · tumor vs normal (RNA) · all OTOP2 data types