OTOL1

Across TCGA pan-cancer cohorts, OTOL1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated OTOL1 data layer compared with 15 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher OTOL1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated OTOL1 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

KIRC, ESCA, and BLCA are the cancer types where OTOL1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	II,III,IV	0.203	0.789	.009	30	view →
ESCA	DFS	Median	All	0.075	0.533	<.001	12	view →
BLCA	DFS	Median	All	0.114	0.626	<.001	12	view →
LIHC	OS	Median	All	0.015	0.784	<.001	6	view →
SKCM	DFS	Median	II,III,IV	0.861	0.660	.019	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

OTOL1–KIRC (OS)

Open the KIRC breakdown →