OTOGL

Across TCGA patient cohorts, OTOGL mutation is significantly associated with the RNA expression of many other genes, with 7,958 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTOGL-associated genes across cancer lineages are FXN, EXO1, and DLGAP5. Each is linked with OTOGL in more than 5 cancer types. Because this analysis shows association rather than direction, both OTOGL-to-partner and partner-to-OTOGL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FXN grouped by OTOGL-low versus OTOGL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOGL→partner) and Y-score (partner→OTOGL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FXN →	+0.358	+1.364	<.001	<.001	3	6
UCEC	EXO1 →	+0.581	+1.385	<.001	<.001	3	6
UCEC	DLGAP5 →	+0.702	+1.595	<.001	<.001	3	6
UCEC	COQ3 →	+0.337	+1.254	<.001	<.001	3	6
UCEC	TCF3 →	+0.562	+1.729	<.001	<.001	3	5
LUAD	EPRS1 →	+0.389	+2.736	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,958 associations by consensus.

FXN by OTOGL expression — UCEC

Explore this box plot interactively →