OTOGL

Across TCGA patient cohorts, OTOGL mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTOGL-associated genes across cancer lineages are ASNS, ATM, and Bad_pS112. Each is linked with OTOGL in more than 5 cancer types. Because this analysis shows association rather than direction, both OTOGL-to-partner and partner-to-OTOGL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by OTOGL-low versus OTOGL-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOGL→partner) and Y-score (partner→OTOGL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ASNS →	+0.489	+3.000	.006	.037	3	6
UCEC	ATM →	-0.575	-1.700	<.001	<.001	3	4
COAD	Bad_pS112 →	-0.140	-1.576	.044	.035	3	4
UCEC	ACC1 →	+0.222	+1.453	.016	.012	3	4
UCEC	Cyclin-B1 →	+0.593	+1.547	<.001	<.001	3	4
UCEC	PCNA →	+0.196	+2.070	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

ASNS by OTOGL expression — BRCA

Explore this box plot interactively →