OTOGL

Across TCGA cell cohorts, OTOGL mutation is significantly associated with the RNA expression of many other genes, with 899 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OTOGL-associated genes across cancer lineages are BFSP2, GAGE12E, and GAGE12H. Each is linked with OTOGL in more than 2 cancer types. Because this analysis shows association rather than direction, both OTOGL-to-partner and partner-to-OTOGL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BFSP2 grouped by OTOGL-low versus OTOGL-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOGL→partner) and Y-score (partner→OTOGL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	BFSP2 →	+0.293	+3.510	.001	.002	3	2
STOMACH	GAGE12E →	+0.166	+4.280	<.001	.001	3	2
STOMACH	GAGE12H →	+0.083	+3.432	<.001	.008	3	2
BLOOD_Lymphoma	LRRD1 →	+0.065	+3.770	.003	.001	3	2
LUNG_NSCLC_LUAD	GAGE1 →	+2.205	+3.906	.001	.001	3	2
LUNG_NSCLC_LUAD	GAGE12J →	+1.116	+2.830	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 899 associations by consensus.

BFSP2 by OTOGL expression — OESOPHAGUS

Explore this box plot interactively →