OTC

Across TCGA patient cohorts, OTC protein abundance is significantly associated with the RNA expression of many other genes, with 7,275 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible OTC-associated genes across cancer lineages are FCGR3B, CXCL1, and CEACAM3. Each is linked with OTC in more than 5 cancer types. Because this analysis shows association rather than direction, both OTC-to-partner and partner-to-OTC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, OTC versus FCGR3B in UCEC, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTC→partner) and Y-score (partner→OTC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FCGR3B →	+1.557	+1.268	<.001	<.001	3	6
UCEC	CXCL1 →	+2.020	+0.938	.002	<.001	3	6
HNSC	CEACAM3 →	+0.770	+1.419	<.001	<.001	3	6
HNSC	FFAR2 →	+1.319	+1.605	<.001	<.001	3	5
UCEC	CXCL3 →	+1.238	+0.962	<.001	<.001	3	5
HNSC	ADGRG3 →	+1.176	+1.528	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,275 associations by consensus.

OTC vs FCGR3B — UCEC

Explore this scatter interactively →