OTC

Across TCGA patient cohorts, OTC mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTC-associated genes across cancer lineages are Annexin-1, ERK2, and PCNA. Each is linked with OTC in more than 2 cancer types. Because this analysis shows association rather than direction, both OTC-to-partner and partner-to-OTC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by OTC-low versus OTC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTC→partner) and Y-score (partner→OTC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.384	+2.341	.047	.019	3	3
UCEC	ERK2 →	+0.152	+1.874	.031	.049	3	2
UCEC	PCNA →	+0.240	+1.847	.002	.008	3	2
UCEC	PDCD4 →	-0.430	-1.874	.013	.049	3	2
UCEC	PRAS40_pT246 →	+0.174	+1.515	.005	.018	3	2
UCEC	ASNS →	+0.446	+1.807	<.001	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Annexin-1 by OTC expression — UCEC

Explore this box plot interactively →