OTC

Across TCGA cell cohorts, OTC RNA expression is significantly associated with the go_rna of many other GO terms, with 1,487 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible OTC-associated GO terms across cancer lineages are Dentinogenesis, Positive regulation of CD4-positive, alpha-beta T cell activation, and Negative regulation of actin filament polymerization. Each is linked with OTC in more than 5 cancer types. Because this analysis shows association rather than direction, both OTC-to-partner and partner-to-OTC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dentinogenesis grouped by OTC-low versus OTC-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OTC→partner) and Y-score (partner→OTC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Dentinogenesis →	-0.908	-0.069	.007	.009	3	6
BONE	Positive regulation of CD4-positive, alpha-beta T cell activation →	-0.083	-0.064	.004	.007	3	5
SOFT_TISSUE	Negative regulation of actin filament polymerization →	-0.076	-0.043	.001	.003	3	5
SOFT_TISSUE	Positive regulation of blood vessel endothelial cell migration →	-0.066	-0.045	.005	.002	3	5
SOFT_TISSUE	Regulation of cell shape →	-0.045	-0.045	.001	.001	3	5
LUNG_SCLC	Bleb assembly →	-0.603	-0.116	.004	.003	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,487 associations by consensus.

Dentinogenesis by OTC expression — SOFT_TISSUE

Explore this box plot interactively →