OSTM1

Across TCGA pan-cancer cohorts, OSTM1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of OSTM1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where OSTM1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types OSTM1 is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

HNSC, COAD, and LSCC are the cancer types where OSTM1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OSTM1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.328	<.001	8	view →
COAD	All	II,III,IV	−0.456	<.001	5	view →
LSCC	All	II,III,IV	−0.226	<.001	5	view →
LUAD	Male	All	−0.197	<.001	4	view →
CCRCC	Male	All	−0.145	.001	2	view →
PDAC	Male	III,IV	−0.663	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

OSTM1–HNSC

Open the HNSC breakdown →