OSTM1

Across TCGA patient cohorts, OSTM1 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSTM1-associated genes across cancer lineages are Endothelial cells, lymphatic Endothelial cells, and mv Endothelial cells. Each is linked with OSTM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSTM1-to-partner and partner-to-OSTM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endothelial cells grouped by OSTM1-low versus OSTM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSTM1→partner) and Y-score (partner→OSTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Endothelial cells →	-0.042	-2.416	.022	.021	1	1
UCEC	lymphatic Endothelial cells →	-0.027	-2.405	.019	.021	1	1
UCEC	mv Endothelial cells →	-0.032	-2.448	.005	.020	1	1
UCEC	Th2 cells →	+0.244	+2.459	.005	.020	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Endothelial cells by OSTM1 expression — UCEC

Explore this box plot interactively →