OSTM1

Across TCGA cell cohorts, OSTM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,494 significant associations in total. BONE shows the largest number of these associations.

The most reproducible OSTM1-associated GO terms across cancer lineages are Sphingolipid metabolic process, Ceramide metabolic process, and Phosphatidylinositol dephosphorylation. Each is linked with OSTM1 in more than 13 cancer types. Because this analysis shows association rather than direction, both OSTM1-to-partner and partner-to-OSTM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sphingolipid metabolic process grouped by OSTM1-low versus OSTM1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OSTM1→partner) and Y-score (partner→OSTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Sphingolipid metabolic process →	+0.084	+1.634	.002	<.001	3	14
OESOPHAGUS	Ceramide metabolic process →	+0.099	+1.677	<.001	.001	3	14
PANCREAS	Phosphatidylinositol dephosphorylation →	+0.066	+1.372	<.001	<.001	3	14
URINARY_TRACT	Cellular response to nitrosative stress →	+0.180	+1.333	<.001	<.001	3	14
LIVER	Transepithelial chloride transport →	+0.245	+1.836	<.001	<.001	3	14
BONE	Pyrimidine nucleotide-sugar transmembrane transport →	+0.094	+1.335	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,494 associations by consensus.

Sphingolipid metabolic process by OSTM1 expression — BONE

Explore this box plot interactively →