Across TCGA pan-cancer cohorts, OSTM1-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated OSTM1-AS1 data layer compared with 1 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher OSTM1-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated OSTM1-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

KIRC, LIHC, and KIRP are the cancer types where OSTM1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	III,IV	0.779	0.491	<.001	66	view →
LIHC	DFS	Tertile	All	0.299	0.566	.002	63	view →
KIRP	DFS	Quartile	II,III,IV	0.475	0.872	<.001	59	view →
HNSC	DFS	Tertile	II,III,IV	0.527	0.266	.002	42	view →
ACC	DFS	Quartile	II,III,IV	0.286	0.676	<.001	33	view →
UVM	DFS	Median	III,IV	0.898	0.487	.018	24	view →
LGG	OS	Tertile	All	0.820	0.928	<.001	20	view →
SARC	OS	Tertile	All	0.754	0.870	.002	18	view →
KICH	OS	Tertile	All	0.556	0.901	.014	12	view →
UCEC	OS	Tertile	All	0.904	0.950	.016	12	view →
CESC	DFS	Median	All	0.799	0.702	.042	10	view →
CHOL	OS	Median	IV	1.000	0.286	.024	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

Exploration

Same gene, other analysis: OSTM1-AS1 tumor-vs-normal RNA expression · all OSTM1-AS1 data types