OSTF1

Across TCGA pan-cancer cohorts, OSTF1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated OSTF1 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher OSTF1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated OSTF1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

COAD, HNSC, and PDAC are the cancer types where OSTF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	0.898	1.000	.016	36	view →
HNSC	OS	Tertile	III,IV	0.973	0.728	.001	33	view →
PDAC	DFS	Median	All	0.933	0.665	.001	28	view →
CCRCC	DFS	Quartile	All	0.874	0.999	.033	4	view →
LSCC	DFS	Median	II,III,IV	0.968	0.885	.027	4	view →
LUAD	OS	Quartile	III,IV	0.264	0.722	.022	2	view →
GBM	OS	Median	All	0.292	0.488	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

OSTF1–COAD (DFS)

Open the COAD breakdown →