OSTF1

Across TCGA patient cohorts, OSTF1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSTF1-associated genes across cancer lineages are EGFR_pY1068, JNK2, and p62 Lck ligand. Each is linked with OSTF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSTF1-to-partner and partner-to-OSTF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by OSTF1-low versus OSTF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSTF1→partner) and Y-score (partner→OSTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.435	-3.000	.002	.037	1	1
UCEC	JNK2 →	+0.290	+3.000	.011	.037	1	1
UCEC	p62 Lck ligand →	+0.450	+3.000	.016	.037	1	1
UCEC	Shc_pY317 →	-0.348	-3.000	<.001	.037	1	1
UCEC	VHL →	-1.282	-3.000	.001	.037	1	1
UCEC	Caspase-8 →	-0.327	-3.000	.024	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

EGFR_pY1068 by OSTF1 expression — UCEC

Explore this box plot interactively →