OSTF1

Across TCGA cell cohorts, OSTF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,571 significant associations in total. BONE shows the largest number of these associations.

The most reproducible OSTF1-associated GO terms across cancer lineages are Negative regulation of actin filament polymerization, Negative regulation of protein polymerization, and Small GTPase-mediated signal transduction. Each is linked with OSTF1 in more than 12 cancer types. Because this analysis shows association rather than direction, both OSTF1-to-partner and partner-to-OSTF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of actin filament polymerization grouped by OSTF1-low versus OSTF1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OSTF1→partner) and Y-score (partner→OSTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of actin filament polymerization →	+0.159	+1.095	.003	.001	3	13
STOMACH	Negative regulation of protein polymerization →	+0.137	+1.622	.001	.001	3	13
BONE	Small GTPase-mediated signal transduction →	+0.074	+2.327	<.001	<.001	3	11
URINARY_TRACT	Actin filament-based movement →	+0.119	+1.888	<.001	<.001	3	11
STOMACH	Positive regulation of proteolysis →	+0.099	+1.687	.008	.001	2	11
LUNG_SCLC	Lactose metabolic process →	+0.537	+0.834	.005	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,571 associations by consensus.

Negative regulation of actin filament polymerization by OSTF1 expression — PANCREAS

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