OSTF1

Across TCGA cell cohorts, OSTF1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible OSTF1-associated genes across cancer lineages are UTF1, OR12D3, and SERPINA7. Each is linked with OSTF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSTF1-to-partner and partner-to-OSTF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UTF1 grouped by OSTF1-low versus OSTF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSTF1→partner) and Y-score (partner→OSTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UTF1 →	+0.017	+3.217	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR12D3 →	+0.025	+5.228	.001	.005	3	1
LUNG_NSCLC_LUAD	SERPINA7 →	+0.006	+5.228	.005	.005	3	1
LUNG_NSCLC_LUAD	OR4K1 →	+0.019	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	GPR101 →	+0.012	+4.887	.004	.009	3	1
LUNG_NSCLC_LUAD	OR4D5 →	+0.019	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

UTF1 by OSTF1 expression — LARGE_INTESTINE

Explore this box plot interactively →