Across TCGA patient cohorts, OSTC mutation is significantly associated with the RNA expression of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSTC-associated genes across cancer lineages are OR5L1, NUTF2P8, and MIR6801. Each is linked with OSTC in more than 1 cancer types. Because this analysis shows association rather than direction, both OSTC-to-partner and partner-to-OSTC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSTC→partner) and Y-score (partner→OSTC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OR5L1 →	+0.044	+7.731	<.001	.009	3	1
UCEC	NUTF2P8 →	+0.173	+3.398	<.001	.001	3	1
UCEC	MIR6801 →	+0.641	+2.806	<.001	.003	3	1
UCEC	IQCF1 →	+0.273	+3.029	.003	.003	3	1
UCEC	OR5J2 →	+0.099	+2.701	.003	.009	3	1
BRCA	RNU4ATAC3P →	+0.315	+7.731	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

Exploration

OSTC survival (RNA) · tumor vs normal (RNA) · all OSTC data types