OSR2

Across TCGA patient cohorts, OSR2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSR2-associated genes across cancer lineages are GAPDH, eEF2, and eIF4E. Each is linked with OSR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSR2-to-partner and partner-to-OSR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by OSR2-low versus OSR2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSR2→partner) and Y-score (partner→OSR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	GAPDH →	+0.971	+2.816	.008	.036	3	2
UCEC	eEF2 →	+0.341	+1.415	.011	.046	3	2
UCEC	eIF4E →	+0.168	+3.183	.033	.009	3	2
UCEC	RAD51 →	+0.130	+3.584	.013	.002	3	2
UCEC	CDK1 →	+0.122	+1.750	.031	.049	3	2
UCEC	A-Raf_pS299 →	-0.147	-2.321	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

GAPDH by OSR2 expression — LUSC

Explore this box plot interactively →