OSR2

Across TCGA cell cohorts, OSR2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OSR2-associated genes across cancer lineages are OR12D3, GPR42, and GK2. Each is linked with OSR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSR2-to-partner and partner-to-OSR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR12D3 grouped by OSR2-low versus OSR2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSR2→partner) and Y-score (partner→OSR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR12D3 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	GPR42 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	GK2 →	+0.008	+4.437	<.001	.004	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.012	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR12D3 by OSR2 expression — LARGE_INTESTINE

Explore this box plot interactively →