OSMR

Across TCGA pan-cancer cohorts, OSMR mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated OSMR data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher OSMR mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated OSMR expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

PDAC, CCRCC, and LUAD are the cancer types where OSMR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.224	0.790	.001	52	view →
CCRCC	OS	Median	All	0.728	0.961	.003	26	view →
LUAD	DFS	Quartile	All	0.360	0.758	.001	24	view →
LSCC	DFS	Quartile	All	0.518	0.776	.033	6	view →
UCEC	DFS	Quartile	All	1.000	0.763	.049	4	view →
HNSC	DFS	Tertile	III,IV	1.000	0.902	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

OSMR–PDAC (OS)

Open the PDAC breakdown →