OSM

Across TCGA patient cohorts, OSM mutation is significantly associated with the RNA expression of many other genes, with 1,627 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSM-associated genes across cancer lineages are RNU6-964P, NF1P12, and RNU7-195P. Each is linked with OSM in more than 1 cancer types. Because this analysis shows association rather than direction, both OSM-to-partner and partner-to-OSM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-964P grouped by OSM-low versus OSM-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSM→partner) and Y-score (partner→OSM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-964P →	+0.487	+3.045	<.001	.008	3	2
UCEC	NF1P12 →	+0.093	+2.259	<.001	.007	3	2
BLCA	RNU7-195P →	+0.605	+5.177	<.001	.007	3	2
UCEC	MIR3651 →	+0.650	+2.563	<.001	<.001	3	1
LUAD	RNU4-74P →	+0.438	+5.099	<.001	.008	3	1
LUAD	LINC01757 →	+0.197	+5.984	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,627 associations by consensus.

RNU6-964P by OSM expression — SKCM

Explore this box plot interactively →