OSM

Across TCGA patient cohorts, OSM mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSM-associated genes across cancer lineages are Heregulin, Mre11, and P-Cadherin. Each is linked with OSM in more than 1 cancer types. Because this analysis shows association rather than direction, both OSM-to-partner and partner-to-OSM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by OSM-low versus OSM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSM→partner) and Y-score (partner→OSM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.156	-3.169	.011	.019	3	1
UCEC	Mre11 →	-0.121	-2.321	.004	.035	3	1
UCEC	P-Cadherin →	-0.186	-2.999	.010	.035	3	1
UCEC	STAT5a →	+0.449	+3.000	.025	.036	3	1
UCEC	Tuberin →	+0.278	+3.009	.040	.019	3	1
UCEC	Caspase-7-cleavedD198 →	+0.841	+2.321	.004	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Heregulin by OSM expression — UCEC

Explore this box plot interactively →