OSM

Across TCGA cell cohorts, OSM RNA expression is significantly associated with the go_rna of many other GO terms, with 2,514 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible OSM-associated GO terms across cancer lineages are Regulation of intracellular protein transport, Negative regulation of myoblast fusion, and Regulation of ubiquitin-dependent protein catabolic process. Each is linked with OSM in more than 7 cancer types. Because this analysis shows association rather than direction, both OSM-to-partner and partner-to-OSM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of intracellular protein transport grouped by OSM-low versus OSM-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OSM→partner) and Y-score (partner→OSM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of intracellular protein transport →	+0.069	+0.101	.004	.008	3	8
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.086	+0.100	.001	.005	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of ubiquitin-dependent protein catabolic process →	+0.045	+0.074	<.001	.004	3	8
LUNG_NSCLC_LUSC	Response to starvation →	+0.044	+0.125	<.001	.002	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of nucleocytoplasmic transport →	+0.067	+0.098	<.001	.008	3	7
PANCREAS	Regulation of protein localization to nucleus →	+0.065	+0.087	.003	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,514 associations by consensus.

Regulation of intracellular protein transport by OSM expression — PANCREAS

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