OSM

Across TCGA cell cohorts, OSM mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OSM-associated genes across cancer lineages are KRT25, RPTN, and RHOXF2. Each is linked with OSM in more than 1 cancer types. Because this analysis shows association rather than direction, both OSM-to-partner and partner-to-OSM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT25 grouped by OSM-low versus OSM-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSM→partner) and Y-score (partner→OSM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KRT25 →	+0.035	+4.643	<.001	.004	3	1
LUNG_SCLC	RPTN →	+0.006	+4.269	<.001	.005	3	1
LARGE_INTESTINE	RHOXF2 →	+0.029	+3.070	.001	.009	3	1
LARGE_INTESTINE	CPO →	+0.104	+3.777	.003	.001	3	1
LARGE_INTESTINE	TKTL2 →	+0.048	+4.772	<.001	<.001	3	1
LARGE_INTESTINE	C1orf189 →	+0.139	+2.791	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

KRT25 by OSM expression — LUNG_SCLC

Explore this box plot interactively →