OSGIN2

Across TCGA patient cohorts, OSGIN2 mutation is significantly associated with the RNA expression of many other genes, with 1,699 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSGIN2-associated genes across cancer lineages are EIF3JP1, PRXL2AP1, and RNA5SP519. Each is linked with OSGIN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSGIN2-to-partner and partner-to-OSGIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF3JP1 grouped by OSGIN2-low versus OSGIN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSGIN2→partner) and Y-score (partner→OSGIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EIF3JP1 →	+0.157	+1.646	<.001	.007	3	2
READ	PRXL2AP1 →	+0.200	+5.421	<.001	.005	3	2
BLCA	RNA5SP519 →	+0.433	+5.329	<.001	.006	3	2
READ	ATP6V1E1P2 →	+0.442	+5.039	<.001	.008	3	2
UCEC	PRAMEF13 →	+0.019	+2.753	<.001	.002	3	2
SKCM	RNU6-519P →	+0.365	+4.114	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,699 associations by consensus.

EIF3JP1 by OSGIN2 expression — UCEC

Explore this box plot interactively →