OSGIN1

Across TCGA patient cohorts, OSGIN1 RNA expression is significantly associated with the mutation status of many other genes, with 12,780 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSGIN1-associated genes across cancer lineages are NFE2L2, CUL3, and KEAP1. Each is linked with OSGIN1 in more than 5 cancer types. Because this analysis shows association rather than direction, both OSGIN1-to-partner and partner-to-OSGIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NFE2L2 grouped by OSGIN1-low versus OSGIN1-high in LUSC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSGIN1→partner) and Y-score (partner→OSGIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	NFE2L2 →	+3.510	+2.504	<.001	<.001	3	6
HNSC	CUL3 →	+3.482	+1.845	.002	<.001	3	4
LUAD	KEAP1 →	+3.807	+2.180	<.001	<.001	3	4
HNSC	TP53 →	+0.438	+0.504	.007	<.001	3	4
HNSC	NRXN1 →	+2.330	+0.818	.003	.008	3	4
UCEC	LRRC4C →	+2.283	+0.998	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,780 associations by consensus.

NFE2L2 by OSGIN1 expression — LUSC

Explore this box plot interactively →