OSGIN1

Across TCGA cell cohorts, OSGIN1 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible OSGIN1-associated genes across cancer lineages are DEFA4 and INSL5. Each is linked with OSGIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSGIN1-to-partner and partner-to-OSGIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by OSGIN1-low versus OSGIN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSGIN1→partner) and Y-score (partner→OSGIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.032	+4.437	<.001	.004	3	1
SKIN	INSL5 →	+0.043	+4.467	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

DEFA4 by OSGIN1 expression — LARGE_INTESTINE

Explore this box plot interactively →